The immunomodulator FTY720 is phosphorylated and released from platelets
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چکیده
منابع مشابه
The immunomodulator FTY720 is phosphorylated and released from platelets.
The novel immunomodulator FTY720 causes lymphocytes from peripheral blood to accumulate in lymphoid tissues. In vivo, FTY720 is phosphorylated to FTY720-P, which binds to the sphingosine 1-phosphate receptor S1P(1). So far, it has been unclear where FTY720-P is produced. We demonstrate that platelets efficiently convert FTY720 to FTY720-P and release it into the extracellular space. This releas...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 2007
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2007.04.053